Vol. 2 No. 4 (2026): 4
Published:
2026-07-15
递增剂量双去甲氧基姜黄素对BALB/c裸鼠A549皮下移植瘤生长及PCNA、MMP-2、MMP-9表达的影响
永捷 戚 (Author)
Article
目的:探讨双去甲氧基姜黄素(bisdemethoxycurcumin,BDMC)对非小细胞肺癌(NSCLC)BALB/c裸鼠皮下移植瘤生长及迁移能力的影响,并验证“递增剂量BDMC可抑制肿瘤生长、下调PCNA、MMP-2和MMP-9表达”的假设。方法:将人NSCLC A549细胞接种于BALB/c裸鼠右前肢腋下,建立皮下移植瘤模型。将成瘤裸鼠随机分为模型组、BDMC低剂量组(25 mg/kg)、BDMC中剂量组(50 mg/kg)、BDMC高剂量组(100 mg/kg)及阳性对照组(顺铂,2 mg/kg),每组10只。各组腹腔注射相应药物,连续14 d。每3...
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Research on Machine Learning High-Frequency Trading Strategies Under Transaction Cost
Weijian Huang, Zhanwei Wang, Wenchang Jiang (Author)
Article
In the field of high-frequency quantitative trading for cryptocurrencies, the industry has long fallen into an algorithm arms race centered on deep learning models such as LSTM and Transformer. Researchers excessively pursue marginal improvements in predictive indicators including Mean Squared Error (MSE) and Directional Accuracy, which leads...
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Research on Machine Learning High-Frequency Trading Strategy of Cryptocurrency Based on Transaction Cost-Aware Filtering
Weijian Huang, Zhanwei Wang, Xianpeng Jiang (Author)
Article
Current machine learning-based quantitative high-frequency trading suffers from a significant Prediction-to-Trading Gap. Academic and industrial research overly focuses on the optimization of model prediction errors while ignoring the devastating impact of real-market trading frictions on strategy returns. Taking the hourly high-frequency...
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Reshaping Alpha with Conditional Probability: A Low-Cost Improvement Path for Index Timing
Weijian Huang, Yuanqi Huang, Xianpeng Jiang (Author)
Article
Direct linear regression prediction of index returns has long been recognized as a challenging task in industry time-series timing research. Constrained by the extremely low signal-to-noise ratio and pervasive nonlinear characteristics of financial data, ordinary least squares (OLS) regression suffers from poor out-of-sample performance and...
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